By Robert A. Maes, Hans Brandenberger
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Extra info for Analytical toxicology for clinical, forensic, and pharmaceutical chemists
Et. al. (1981) Phenytoin monotherapy for epilepsy: a long term prospective study, assisted by serum level monitoring, in previously untreated patients. Epilepsia 22, 475-488. 36. Cobos, J. E.
3. The drug concentration should not be predictable in an individual patient based on the administered dose. 4. Variability in the concentration-effect relationship should be less than the variability in the dose-concentration relationship. 5. There is a well-defined "target range" where the patient experiences maximal therapeutic benefit with minimal risk of toxicity. 6. Attainment and maintenance of biological fluid drug concentrations in the optimal target range by adjustment of dose strength and frequency leads to greater benefit than can be achieved by the exercise of sound clinical judgement.
But the discriminating properties of an UV scan are not as effective as a mass spectrum, and the number of compounds which are actually identified is low (a few hundred) compared to the mass spectra libraries (more than 150000). 6 Thin layer chromatography (TLC) Some papers have discussed the use of standardised TLC systems in toxicological analysis (15, 16). This technique is very efficient, particularly because it gives an immediate vision of the presence or absence of drugs, but it suffers from lack of sensitivity for the detection of many modern drugs which are active at low concentrations.
Analytical toxicology for clinical, forensic, and pharmaceutical chemists by Robert A. Maes, Hans Brandenberger