By Marc A. Williams
Pt. 1. floor amendment options -- pt. 2. Analytical ideas and functions
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Extra resources for Allergens and respiratory pollutants: The role of innate immunity
HLA-DR, HLA-DQ and HLA-DP) to the appropriate CD4+ T helper (Th) cell, which upon DC-mediated activation undergoes clonal expansion. The CD4+ Th cell is thus licensed to differentiate to either a Th1 subgroup that is functionally responsible for predominantly cell-mediated immune and antibody-specific responses that provides protection against intracellular pathogens or a Th2 subgroup that predominantly facilitates protection against extracellular infections like parasitic infections as well as promoting humoral-mediated immune responses.
Atopic asthma is often considered a disease of developed countries. Clinically, asthma is largely characterized by airway inflammation coupled with transient narrowing of the airways (bronchoconstriction), secretion and deposition of mucus in the airways, resulting in extreme difficulty in breathing, wheezing, repetitive cough and, in the severest form, coma and death. An introduction to allergic inflammation 13 There is no cure for asthma, although the disease can be clinically managed. In the US alone an ever-increasing number of individuals are presenting with asthma and seasonal allergies such that well over 20 million people have asthma in the US and more than 50 percent of those with asthma present with the atopic or allergic form of the disease.
Our work has supported the growing concept that environmental PM species may drive allergic immunity and possibly either promote or exacerbate pre-existing allergic asthma. Though we have not empirically determined the notion of exposure to particulate pollutants and pro-allergic immunity, one of the central tenets of allergic respiratory diseases like asthma is a dominant Th2-biased immune response. We have also appreciated in this chapter that dendritic cells are the key sentinels of the innate immune system that evolved to rapidly translate diverse environmental cues into signals that activate adaptive immunity following their interactions with pathogenic microorganisms or environmental particulates at the mucosal interface.
Allergens and respiratory pollutants: The role of innate immunity by Marc A. Williams