By Chong-Ren Yang, Osamu Tanaka

ISBN-10: 0080544541

ISBN-13: 9780080544540

ISBN-10: 0444501800

ISBN-13: 9780444501806

Hardbound. within the plant state a number of chemical elements happen in a glycoside shape (conjugation with sugar). Glycosides are vital, secondary metabolites. The structural variety is due to the the gigantic quantity of sorts and stereochemical configurations of the sugar part. Aglycones belong to terpenoid, steroid, flavonoid, quinonoid, lignan, different uncomplicated phenolics, and isothiocyanate. in spite of the fact that, organic actions of glycosides are, in lots of situations, at risk of the character of sugar moieties, even supposing their aglycone is the same.Since the 80s, plant glycosides were attracting an expanding quantity of curiosity from botanists and phytochemists world-wide for the subsequent purposes: - they're tricky to isolate and purify- they've got a vital organic functionality in plants and noteworthy organic actions- they seem to be a extremely important source of typical drugs, health and wellbeing meals, cosmetics and f

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Et. May and R. sacra S. H, Fu, Crassulaceae), 2~ and those glycosides were found to show antiallergic activity. , I O HO~-~,-, soyasaponinI (49) 9RI=OH, R2=H dehydrosoyasaponin I (50) 9R], R2=O ~'HO H OH Chart 9. Structure of Saponin constituents from KidnyBean As an extension of this work, we have examined the inhibitory activity of sandosaponins and soyasaponins on histamine release from rat peritoneal exudate cells induced by an antigenantibody reaction. The new saponins sandosaponins A (46) and B (47) showed more potent inhibitory activity than soyasaponin V (48) as shown in Table 3.

9These results strongly suggested that P. notoginseng might be a valuable anti-tumorpromoter and chemopreventive agent in chemical carcinogenesis, and that one of the active principles of P. notoginseng might be ginsenoside Rgl. In the case of the hepatitis or the prevention of cancer relapse, we should consider to apply the chemopreventive agents such as P. notoginseng to reduce the severe side actions of anticancer agents. For the application of natural products to chemoprevention, we have many problems to be solved, and one of the most important problem is the inhibitory mechanisms of these compounds on chemical carcinogenesis.

1996) Nat. Med. 50, 176. 8. , Masuda, H. and Mizutani, K. (1996) "Saponins Used in Food and Agriculture" Waller, G. R. and Yamasaki, K. eds. (Plenum Press, New York, London) pp. 1-11. 9. , Hosokawa, I. and Mihashi, K. (1974) Chem. Pharm. Bull. 22, 2164. 10. , Sankawa, U. and Ebizuka, Y. (1995) Nat. Med. 49, 33, and references cited therein. 11. , Sankawa, U. and Ebizuka, Y. (1996) Phytochemistry 41, 725. 12. Inoue, K. and Ebizuka, Y. (1996) FEBS Letters 378, 157. 13. , Yamamoto, K. and Ebizuyka, Y.

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Advances in Plant Glycosides, Chemistry and Biology, Proceedings of the International Symposium in Plant Glycosides by Chong-Ren Yang, Osamu Tanaka

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