By Keith Green (auth.), Keith Green, Henry F. Edelhauser, Robert B. Hackett, David S. Hull, David E. Potter, Ramesh C. Tripathi (eds.)

ISBN-10: 146137720X

ISBN-13: 9781461377207

ISBN-10: 1461559375

ISBN-13: 9781461559375

This quantity represents the complaints of the 5th Congress of the overseas Society of Ocular Toxicology (ISOT), which was once held on the Grove Park hotel and lodge in Asheville, North Carolina, October 13-17, 1996. we're thrilled to provide this quantity to the ophthalmic group, particularly people with an important curiosity in ocular toxicol­ ogy. The 5th Congress was once built round issues in terms of ocular drug metabolism, the ocular pathophysiological results of nitric oxide, govt matters in terms of using replacement equipment for toxicity trying out, and a workshop that encompassed comparisons of either in vitro as opposed to in vivo types in addition to diverse animal versions. the result of this congress, embodied during this quantity, is a contribution to the methodologies at the moment hired or below improvement and to varied drug or actual results on varied ocular tissues. whereas the point of interest of this court cases is on ocular results of substances or different fabrics, a few of the contributions take care of subject matters that experience a much wider curiosity. The workshop about the use of other version platforms and the alternative of the easiest animal version for drug trying out covers quite a lot of pursuits that ex­ has a tendency some distance past particular ocular results. this is often very true within the sector of different equipment and within the collection of the simplest animal version for exam of alternative disorder entities.

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A normal lens contains nanomole quantities of PSSG and PSSC, at the level of 2-5% of free glutathione (GSH). However, these compounds can be elevated extensively in human cataractous lenses as well as in oxidative stress-induced cataracts in human and animal lenses. The latter include cataracts induced by hyperbaric oxygen, naphthalene, ultraviolet light, diquat and hydrogen peroxide. Even the Emory mouse cataract, a genetic cataract occurring in aging mice, contains a significant amount of the protein-thiol mixed disulfides.

0 I compared to 10. 5 molii. tions remained intact and endothelial paraceIIuIIar permeability was unaltered. 6 Endothelial paracellular permeability is also unaffected by 12(R)HETE (Table 2), It can be concluded that the corneal swelling that occurs when 12(R)HETE is perfused to the corneal endothelium results from the inhibition of the endothelia pump function. Our results agree with past studies that show that l2(R)HETE can lower intraocular pressure by inhibiting ciliary body Na+/K+ ATPase 7 and that corneal epithelial Na+/K+ can be inhibited by 12(R)HETE.

Masferrer JL, Rimarachin JA, Gerritsen ME, Falck JR, Yadagiri P, Dunn MW Schwartzman ML. 12(R)-hydroxyeicosatrienoic acid, a potent chemotactic and angiogenic factor produced by the cornea. Exp. Eye Res. 1991 ;52:417-424. 99. Ford-Hutchinson AW, Bray MA, Doig MV, Shipley ME, Smith MJH. Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes. Nature 1980; 286:264-265. 100. Folkman J, Klagsbum M. Angiogenic factors. Science 1987; 235:442-447. 101.

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Advances in Ocular Toxicology by Keith Green (auth.), Keith Green, Henry F. Edelhauser, Robert B. Hackett, David S. Hull, David E. Potter, Ramesh C. Tripathi (eds.)

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