By Keith Green (auth.), Keith Green, Henry F. Edelhauser, Robert B. Hackett, David S. Hull, David E. Potter, Ramesh C. Tripathi (eds.)

ISBN-10: 146137720X

ISBN-13: 9781461377207

ISBN-10: 1461559375

ISBN-13: 9781461559375

This quantity represents the complaints of the 5th Congress of the overseas Society of Ocular Toxicology (ISOT), which was once held on the Grove Park hotel and lodge in Asheville, North Carolina, October 13-17, 1996. we're thrilled to provide this quantity to the ophthalmic group, particularly people with an important curiosity in ocular toxicol­ ogy. The 5th Congress was once built round issues in terms of ocular drug metabolism, the ocular pathophysiological results of nitric oxide, govt matters in terms of using replacement equipment for toxicity trying out, and a workshop that encompassed comparisons of either in vitro as opposed to in vivo types in addition to diverse animal versions. the result of this congress, embodied during this quantity, is a contribution to the methodologies at the moment hired or below improvement and to varied drug or actual results on varied ocular tissues. whereas the point of interest of this court cases is on ocular results of substances or different fabrics, a few of the contributions take care of subject matters that experience a much wider curiosity. The workshop about the use of other version platforms and the alternative of the easiest animal version for drug trying out covers quite a lot of pursuits that ex­ has a tendency some distance past particular ocular results. this is often very true within the sector of different equipment and within the collection of the simplest animal version for exam of alternative disorder entities.

Show description

Read or Download Advances in Ocular Toxicology PDF

Similar toxicology books

Preclinical Development Handbook: Toxicology - download pdf or read online

A transparent, simple source to lead you thru preclinical drug developmentFollowing this book's step by step assistance, you could effectively begin and whole serious levels of preclinical drug improvement. The booklet serves as a basic,comprehensive connection with prioritizing and optimizing leads, toxicity, pharmacogenomics, modeling, and laws.

Download PDF by Hans-Peter Lipp: Anticancer Drug Toxicity: Prevention, Management, and

Containing the most recent findings at the toxicity of quite a lot of chemotherapeutic brokers, this up to the moment reference deals specialist analyses at the pharmacokinetic-pharmacodynamic and pharmacokinetic-toxicodynamic relationships of anticancer compounds. Anticancer Drug Toxicity ·explores healing drug tracking (TDM) as a style of maximizing the efficacy, and minimizing the hazards, of chemotherapy ·presents an unlimited quantity of scientific pharmacokinetic information on cytostatic medicinal drugs ·offers a complete class of toxicity styles linked to using cytotoxic medicines ·analyzes the pharmacokinetics of alkylating brokers, platinum compounds, anthracyclines, antimetabolites, semisynthetic podophyllotoxin- and camptothecin derivatives, mitotic inhibitors, and different cytotoxic brokers ·highlights the pharmacogenetics of 6-mercaptopurine and its scientific importance ·explicates toxicity with regards to the lungs, kidneys, middle, and gonads ·examines issues brought on by asparaginase arrangements ·reviews varieties of secondary malignancy corresponding to leukemias, ovarian melanoma, testicular melanoma, breast melanoma, secondary strong neoplasias, and Hodgkin's disorder ·clarifies the certainty of toxicity as a very important aspect in supportive administration of melanoma remedy ·and extra!

Read e-book online Basic and Clinical Pharmacology 12/E PDF

The main up to date, accomplished, and authoritative pharmacology textual content in overall healthiness medication improved by means of greater than 300 illustrations -- many in complete colour equipped to mirror the syllabi in lots of pharmacology classes and in built-in curricula, simple & scientific Pharmacology, 12e covers the $64000 techniques scholars want to know concerning the technological know-how of pharmacology and its program to scientific perform.

Download PDF by Peter J. Tarcha: Polymers for Controlled Drug Delivery

Polymers for managed Drug supply addresses the demanding situations of designing macromolecules that carry healing brokers that functionality thoroughly and in live performance with residing organisms. The ebook basically discusses periods of polymers and polymeric automobiles, together with particulates, resembling latexes, coacervates, ion-exchange resins, and liposomes, in addition to non-particulate cars reminiscent of enteric coatings, mediators, and bioadhesives.

Additional resources for Advances in Ocular Toxicology

Sample text

A normal lens contains nanomole quantities of PSSG and PSSC, at the level of 2-5% of free glutathione (GSH). However, these compounds can be elevated extensively in human cataractous lenses as well as in oxidative stress-induced cataracts in human and animal lenses. The latter include cataracts induced by hyperbaric oxygen, naphthalene, ultraviolet light, diquat and hydrogen peroxide. Even the Emory mouse cataract, a genetic cataract occurring in aging mice, contains a significant amount of the protein-thiol mixed disulfides.

0 I compared to 10. 5 molii. tions remained intact and endothelial paraceIIuIIar permeability was unaltered. 6 Endothelial paracellular permeability is also unaffected by 12(R)HETE (Table 2), It can be concluded that the corneal swelling that occurs when 12(R)HETE is perfused to the corneal endothelium results from the inhibition of the endothelia pump function. Our results agree with past studies that show that l2(R)HETE can lower intraocular pressure by inhibiting ciliary body Na+/K+ ATPase 7 and that corneal epithelial Na+/K+ can be inhibited by 12(R)HETE.

Masferrer JL, Rimarachin JA, Gerritsen ME, Falck JR, Yadagiri P, Dunn MW Schwartzman ML. 12(R)-hydroxyeicosatrienoic acid, a potent chemotactic and angiogenic factor produced by the cornea. Exp. Eye Res. 1991 ;52:417-424. 99. Ford-Hutchinson AW, Bray MA, Doig MV, Shipley ME, Smith MJH. Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes. Nature 1980; 286:264-265. 100. Folkman J, Klagsbum M. Angiogenic factors. Science 1987; 235:442-447. 101.

Download PDF sample

Advances in Ocular Toxicology by Keith Green (auth.), Keith Green, Henry F. Edelhauser, Robert B. Hackett, David S. Hull, David E. Potter, Ramesh C. Tripathi (eds.)


by Daniel
4.3

Rated 4.11 of 5 – based on 39 votes