By Shayne C. Gad
Acute toxicology checking out offers the 1st defensive line opposed to in all likelihood harmful chemical compounds. This e-book is a whole and sensible advisor to accomplishing and analyzing all regulatory required and familiar acute toxicity exams. It offers certain protocols for the entire universal try designs and reports their improvement and pursuits. Acute Toxicology trying out, moment Edition will curiosity not just employees within the pharmaceutical undefined, but additionally researchers and scholars in toxicology and public health.
* Over a hundred tables summarizing and studying results
* entire assurance of all significant try out designs and their boundaries and advantages
* present prestige of other try designs and types
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Percutaneous Absorption. Dekker, New York. Choman, B. R. (1963). Determination of the response of skin to chemical agents by an in vitro procedure. J. Invest. Dermatol. 44, 177-182. Code of Federal Regulations (CFR) (1984). Transportation, Title 49: Part 173, Appendix A - Method of Testing Corrosion to Skin, Revised; November 1. Consumer Product Safety Commission (CPSC) (1980). Federal Hazardous Substances Act Regulations, CFR 150, 41. Dannenberg, A. , Moore, K. , Schofield, B. , Pula, P. , and Bassett, D.
Maibach, H. , and Akers, W. A. (1972). A comparison of rabbit and human skin response to certain irritants. Toxicol. Appl. Pharmacol. 21,369-382. , and Ferguson, T. F. M. (1976). The effect of surfactants upon rat peritoneal mast cells in vitro. Fd. Chem. Toxicol. 14, 425. Reinhardt, C. , and Spengler, J. (1987). Validation of three cell toxicity tests and the hen's egg test with guinea pig eye and human skin irritation data. In Alternative Methods in Toxicology (A. M. ), Vol. 5. Liebert, New York.
A r e we asking one or more of these questions repeatedly? For example, does X (an event or effect) develop at 30, 60, or 90+ days and/or does it progress/regress or recover? w W h a t is our model to be in answering these questions? Is it appropriate and acceptably sensitive? II. , separate major variable to be studied): - - H o w is the variable of interest to be measured? - - W h a t is the nature of the data generated by the measure? Are we getting an efficient set of data? )? - - A r e there possible interactions between measurements?
Acute Toxicology Testing by Shayne C. Gad