By J.K. Aronson (Eds.)

ISBN-10: 0444505121

ISBN-13: 9780444505125

The negative effects of gear Annual is designed to supply a serious and updated account of recent info with regards to opposed drug reactions and interactions from the clinician's standpoint. below the supervision of the sequence editors, a world group of specialist authors have accrued jointly the most recent info on hostile drug results from the foreign literature. as well as describing new stories of difficult drug results, the authors have subjected these experiences to serious research, atmosphere them into context by way of medical relevance and significance, and cross-referring to earlier experiences the place worthy. New hostile results are pronounced and evaluated and formerly stated hostile results are re-evaluated within the mild of the latest info. a different characteristic is the studies, within which chosen hostile results are mentioned extensive. using the e-book is more advantageous by way of separate indexes, permitting the reader to go into the textual content via drug identify, adversarial influence identify, or drug interplay. the present Annual is the 1st replace of the normal encyclopaedic paintings during this box, http://www.elsevier.nl/locate/isbn/0444500936Meyler's unwanted side effects of gear, Fourteenth version, which used to be released in December 2000.

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A patient who took an overdose of trazodone (3 g) had sinus bradycardia (57 bpm) and a prolonged QTc interval (607 msec). The abnormal QTc interval gradually normalized over the next 3 days with supportive hospital treatment (47A). This suggests that overdoses of trazodone (or perhaps therapeutic doses in predisposed individuals) could be associated with QTc prolongation. Drug interactions Trazodone is related to nefazodone (see above) but probably potentiates 5-HT neurotransmission less. Trazodone is often added to MAOIs and SSRIs at low doses (50-150 mg/day) as a hypnotic, but such combinations can rarely provoke the serotonin syndrome.

She presented a year later with a new heart murmur and eventually required isolated aortic valve replacement. Pathological evaluation of the excised aortic valve was consistent with that described with fen-phen use. A 44-year-old woman, previously treated with appetite suppressants, developed valvular disease consistent with the effects of fen-phen. She had an identical twin who, despite having been treated with the same anorectic medication, remained symptomfree and without abnormal echocardiogruphy.

Fluvoxamine inhibits CYP1A2, and a low dosage (50 mg/day) produced a 225% increase in plasma thioridazine concentrations in 10 patients with schizophrenia (25c). This was not reflected in an increased incidence of clinical adverse events; however, thioridazine prolongs the QTc interval, which was not measured. Drug interactions leading to the serotonin syndrome usually result from pharmacodynamic mechanisms. 5 mg/day) for 5 weeks for the treatment of obsessivecompulsive disorder (26A). Within 4 days of starting erythromycin (200 mg bd) the child began to feel anxious; this was followed over the next 10 days by panic, restlessness, irritability, tremulousness, and confusion.

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A world-wide survey of new data and trends in adverse drug reactions by J.K. Aronson (Eds.)


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