By Ernest Hodgson

ISBN-10: 047046206X

ISBN-13: 9780470462065

ISBN-10: 0470617659

ISBN-13: 9780470617656

A Textbook of contemporary Toxicology is a special source that offers either scholars and practitioners with a wide-ranging, obtainable evaluate of the self-discipline. appropriate for classes in environmental, pharmacological, clinical, and veterinary toxicology, this crucial textual content beneficial properties chapters written by way of specialists who deal with various key topics.The Fourth variation contains extra chapters on new techniques to toxicology - molecular tools (-omics: toxicogenomics, proteomics, and metabolomics), bioinformatics, and structures biology – and maintains the legacy of its predecessors to supply updated insights into acute toxicity and chemical carcinogenesis, organ toxicity, in vitro and in vivo toxicity checking out, ecological possibility evaluate, and plenty of different parts of toxicology that support foster a superb comprehension of the field.Also featured within the Fourth variation are end-of-chapter questions and a strategies guide on hand individually for tutorial adopters.

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1 Application of Human Cell Lines Retaining Differentiated Properties for the Study of Toxic Effects and a Comparison with Primary Human Hepatocytes Cell Type Cell lines SK-N-SH HepG2 Caco-2 Source Human neuroblastoma Human hepatoblastoma Human colon adenocarcinoma Primary hepatocyte Differentiated Cell Type Toxicant Neuron Anesthetic N2O Hepatocyte Cyclophosphamide (antineoplastic) Rifampicin (PXR ligand) Arsenic Intestinal epithelial cell Fipronil, fipronil sulfoxide Deltamethrin (pyrethroid) Permethrin (pyrethroid) DEET (N,N-diethyl-metatoluamide) (repellent) Chlorpyrifos (OP) PXR, pregnane X receptor; OP, organophosphorus.

After suitable preparation of the cells, they are treated with an antibody (the primary antibody) which binds to the protein of interest. An antibody that binds to the primary antibody (the secondary antibody) is then allowed to bind and form an antigen–primary antibody–secondary antibody complex. The detection system generally consists of IMMUNOCHEMICAL TECHNIQUES 1. Electrophoresis C − 2. Transfer Gel T 25 3. Block + Membrane Membrane Milk protein soln. 4. Incubate with primary antibody Primary antibodies 5.

New York: McGraw-Hill, 2001, 1236 pp. Smart, R. C. and E. Hodgson, eds. Molecular and Biochemical Toxicology, 4th ed. Hoboken, NJ: Wiley, 2008, 901 pp. , ed. Encyclopedia of Toxicology, 2nd ed. Oxford, UK: Elsevier, 2005, 4 volumes. 14 INTRODUCTION TO TOXICOLOGY SAMPLE QUESTIONS 1. Briefly define the following terms: a. Toxicology b. Poison c. Genomics d. Proteomics e. Metabolomics 2. Toxicity has been described as a cascade of events initiated by exposure to a harmful chemical. Name the principal steps in this cascade.

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A Textbook of Modern Toxicology, 4th Edition by Ernest Hodgson

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