By Ernest Hodgson

ISBN-10: 047046206X

ISBN-13: 9780470462065

A Textbook of recent Toxicology is a distinct source that offers either scholars and practitioners with a wide-ranging, available evaluation of the self-discipline. compatible for classes in environmental, pharmacological, clinical, and veterinary toxicology, this crucial textual content beneficial properties chapters written via specialists who deal with a number key topics.The Fourth variation contains extra chapters on new ways to toxicology - molecular equipment (-omics: toxicogenomics, proteomics, and metabolomics), bioinformatics, and structures biology – and keeps the legacy of its predecessors to supply up to date insights into acute toxicity and chemical carcinogenesis, organ toxicity, in vitro and in vivo toxicity trying out, ecological chance overview, and plenty of different components of toxicology that aid foster an exceptional comprehension of the field.Also featured within the Fourth version are end-of-chapter questions and a ideas handbook to be had individually for tutorial adopters.

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Radioimmunoassay (RIA) is a very sensitive method used to measure minute quantities of an antigen. Since this method is most often used to measure drugs, toxicants, and other xenobiotics, the antigen used to produce the antibody is the small molecule (hapten) linked covalently to a protein. Among the techniques used in the actual measurement is the antigen capture method, in which the competition between radiolabeled antigen and the unlabeled antigen in the sample is the most common. Depending upon the design of the method, enzyme-linked immunosorbent assay (ELISA) can be used to measure either antigens or antibodies in mixtures by using enzymatic-mediated detection of the corresponding immobilized immune complex.

This mixture of antibodies can be isolated from the serum of the treated animal and is known, collectively, as polyclonal antibodies. 5). Because of the multiple sites for binding, polyclonal antibodies are highly reactive. They are also relatively easy to produce. Monoclonal antibodies, although more difficult to produce are, on the other hand, more specific. The advantages and disadvantages of each must be considered to determine which is the antibody of choice for a particular application. The most important immunochemical methods include the following: Immunolocalization is a technique for identifying the presence of a protein within the cell, its relative abundance, and its subcellular localization.

Serine is replaced by alanine to study the role of posttranslational modifications involving phosphorylation) is expressed in place of the wild-type gene. A general, but more detailed and specific, account of these methods may be found in Smart (2008) and Oleksiak (2008) (see Bibliography). 4 IMMUNOCHEMICAL TECHNIQUES Most of the recently developed methods for the detection, characterization, and quantitation of proteins (Leblanc, 2008) are immunoassays based on the fact that proteins are antigens, compounds that can be recognized by an antibody.

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A textbook of modern toxicology by Ernest Hodgson


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