By David Woolley, Visit Amazon's Adam Woolley Page, search results, Learn about Author Central, Adam Woolley,

ISBN-10: 1420043145

ISBN-13: 9781420043143

This useful, effortless, and informative textual content surveys simple ideas of toxicology. it truly is a useful advisor to comparing toxicity and comparable information, drawing close toxicity trying out and interpretation, and realizing the techniques of chance prediction and threat overview and management.

A advisor to functional Toxicology:

  • examines the best way to review quite a few teams of chemicals—pharmaceuticals, cosmetics, and agrochemicals
  • provides insights on toxicity choice, normality and naturality, prediction, and regulation

Two all-new chapters cover:

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Additional info for A Guide to Practical Toxicology: Evaluation, Prediction, and Risk, Second Edition

Example text

Of these, the usual example is the central nervous system, another tissue with a large functional reserve that can be overwhelmed by insidious toxic actions over a period of years. CELLULAR BASIS AND CONSEQUENCES OF TOXIC CHANGE With the exception of a few substances that are corrosive, direct effects of toxic substances are expressed in individual cells. According to the extent of exposure (dose), the number of cells affected increases to the point where the whole organ or tissue is changed, biochemically or morphologically.

Constant low intake at slightly raised levels can produce gradual accumulation over many years, which ultimately results in renal failure. Accumulation in bone is a feature of toxicity of lead and strontium, which is a cause for concern if the strontium is the radioactive isotope. Bisphosphonates, used in the treatment of osteoporosis, also bind tightly to bone and this is a source of some of their toxicity. Environmental accumulation is also a factor to consider because it can have dire consequences, as illustrated by concentrations of fat-soluble compounds such as DDT, which increase in concentration up the food chain, as in bird of prey populations.

Related to diet are lifestyle factors such as smoking and alcohol consumption, which can also influence expression of toxicity. Occupation Occupation can determine the likelihood of toxic expression, either directly or indirectly. Exposure to vinyl chloride was associated with a rare liver cancer, hemangiosarcoma, its rarity and presence in a clearly defined segment of the population lead to epidemiological identification of the cause. In uranium miners, there was a greatly increased probability of lung cancer, in those who smoked.

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A Guide to Practical Toxicology: Evaluation, Prediction, and Risk, Second Edition by David Woolley, Visit Amazon's Adam Woolley Page, search results, Learn about Author Central, Adam Woolley,


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